

The problem according to extrwi, who says they've spoken with Bethesda, is that the update hitting Skrim SE alongside the Anniversary Edition will compile the game with a newer version of Visual Studio-and that will have a side-effect of breaking the known routes to tap into it.

Many, many mods rely on SKSE, and some mods tap deeper into Skyrim in other ways. SKSE is a tool which lets mods do more than Skyrim's official mod tools allow, tapping deeper into the game to do fancier things.
